Today’s meeting with Angus was interrupted by champagne (welcome) and two fire alarms (less welcome) but we still managed to talk about a lot. Mostly about the narration, but about a couple of other points too.
– The mRNA backbone is too thick, compared to the other organelles it’s really tiny so I need to fix this. There are also proteins bound to it at all times (“heterogeneous mRNA binding proteins,” such as hnRNP), so I should show them.
– Sometimes the animatic is not quite clear whether we are in the nucleus or the cytoplasm. The colouring and shading, therefore, should be very different to make it more clear (or introduce the environment in the narration).
A few amendments to the animatic narration:
– It may be worth mentioning that p53 is simply one of the most important in a great number of proteins responsible for tumour suppression. This is not imperative though – it depends on whether I can find a way to fit it in that doesn’t sound clumsy.
– What is imperative is that unchecked DNA damage does not always result in cancer – normally it results in apoptosis. Only if the UV rays damage the genes responsible for regulating cell division, does a tumour form.
– “p53 is now free to initiate…” is not technically correct. Rather, “p53 is no longer degraded and now quickly accumulates (Angus’ analogy was that of water draining away, being stopped by a plug).”
– It is worth saying (probably at the end) that the reason for many cancers forming is an abnormailty in the p53 (or the p14) gene.







